Flumazenil has a shorter half-life than most BZDs and so rapid resedation can occur after apparent recovery. In addition, antiseizure medication should be readily available in the event of a seizure being triggered. Therefore, it should be given together with ECG monitoring if the history is vague and toxicology results are not yet available. Furthermore, flumazenil can unmask dysrhythmias in patients who have also taken a prodysrhythmic drug (e.g., tricyclic antidepressants or carbamazepine). It should also be avoided in those patients known to be taking drugs that can increase the risk of seizures, such as tricyclic antidepressants, and where other respiratory depressants have been coingested or if the patient has an undifferentiated coma. It is contraindicated in BZD-dependent patients because of the risk of provoking seizures. The risks of flumazenil often outweigh the benefits.įlumazenil can be used in patients who are first-time or infrequent BZD users where the likelihood of BZD overdose is high and there are no known contraindications. Flumazenilįlumazenil reverses CNS depression but does not reliably reverse respiratory depression. Toronto, Canada: Hogrefe & Huber Publishing 2006. Clinical handbook of psychotropic drugs, 16th ed. If there is cardiorespiratory depression, pure BZD overdose is unlikely, and treatment should be focused on cardiorespiratory and hemodynamic support, and treating other causes such as alcohol excess or opioid overdose. Acute management consists of maintaining airway, respiration, and hemodynamic support while excluding other diagnoses. Supportive careĬlinical treatment of overdose is by symptom management. Illegal drugs: A complete guide to their history, chemistry, use and abuse. Once the diagnosis has been confirmed, they require only observation until metabolism of the BZD leads to a natural recovery. The doctor also watched you closely to make sure you were recovering safely.Most patients with pure benzodiazepine (BZD) overdose present with mild central nervous system (CNS) depression, particularly sedation with no respiratory depression. And it may turn your stool black for a few days. This is to help remove the benzodiazepine from your digestive system.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |